ENHANCE
Healthspan & Longevity Support*
- Promotes Longevity, Cellular Renewal & Autophagy
- Supports Heart Health & Mitochondrial Free Radicals
- Assists Cellular Detox & Optimizes Nrf2 Pathways
- Supports Stamina + Endurance & Protein Synthesis
- Maintains Lipid & Blood Sugar Regulation + Energy Production
Active Ingredients: Arginine Alpha-Ketoglutarate, Trimethylglycine, Bergamot Orange Extract, Bergamonte®, Epigallocatechin Gallate, Taxifolin, Spermidine
Other Ingredients: Vegetable Capsule (Hypromellose, Titanium Dioxide)
HOW
Take 3 capsules daily with water or as directed by your healthcare practitioner.
WHEN
Daily
DOSE
3 Capsules
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Benefits
- Promotes Longevity, Cellular Renewal & Autophagy
- Supports Heart Health & Mitochondrial Free Radicals
- Assists Cellular Detox & Optimizes Nrf2 Pathways
- Supports Stamina + Endurance & Protein Synthesis
- Maintains Lipid & Blood Sugar Regulation + Energy Production
-
Ingredients
Active Ingredients: Arginine Alpha-Ketoglutarate, Trimethylglycine, Bergamot Orange Extract, Bergamonte®, Epigallocatechin Gallate, Taxifolin, Spermidine
Other Ingredients: Vegetable Capsule (Hypromellose, Titanium Dioxide)
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How To Use
HOW
Take 3 capsules daily with water or as directed by your healthcare practitioner.
WHEN
Daily
DOSE
3 Capsules
ENHANCE
Formulation
Alpha-Ketoglutarate
- Found In
- Citrus Fruits, Berries, Tomatoes, Spinach (in small amounts)
- Source
- Arginine Alpha-Ketoglutarate
- Benefits
- Blood Pressure, Energy Production
- Science
- 337 published articles
Citrus Bergamot
- Found In
- Bergamot Fruit (Citrus bergamia)
- Source
- Bergamonte®
- Benefits
- Cholesterol, Immune System, Mood, Mental Alertness
- Science
- 471 published articles
Trimethylglycine
- Found In
- Wheat, Beets, Quinoa, Seafood
- Source
- Betaine Anhydrous
- Benefits
- Immune Function, Liver Health, Athletic Performance
- Science
- 9,341 published articles
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Epigallocatechin Gallate
- Found In
- Green Tea
- Source
- Camellia sinensis
- Benefits
- Antioxidant, Mood, Calming Support, Memory
- Science
- 7,138 published articles
Taxifolin
- Found In
- Onions, Milk Thistle, French Maritime Pine Bark
- Source
- Dihydroquercetin
- Benefits
- Liver Health, Detoxification, Brain Health, Immune Function
- Science
- 1,083 published articles
Spermidine
- Found In
- Wheatgerm, Soya beans, Mushrooms, Mature Cheeses
- Source
- Combination of 14-Butanediamine and SAMe
- Benefits
- Energy, Heart, Brain Health
- Science
- 14,420 published articles
Healthspan & Longevity Support*
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OVERVIEW
Enhance is a cutting-edge dietary supplement formulated to support longevity and promote healthy aging. As we age, our cells undergo transformations that impact our well-being and lifespan, including diminished mitochondrial function, reduced autophagy, and decreased cellular renewal. Enhance leverages a precise blend of six key ingredients, including Arginine Alpha-Ketoglutarate (AAKG), Trimethylglycine (TMG), Bergamot Orange Extract, Epigallocatechin Gallate (EGCG), Taxifolin, and Spermidine. These ingredients have demonstrated efficacy in promoting healthspan, optimizing epigenetic aging, and supporting mitochondrial function and autophagy, thus facilitating cellular renewal. By targeting crucial aspects of cellular function such as mitochondrial health, oxidative stress, gene expression, and cellular renewal, Enhance offers a comprehensive approach to support healthy aging and optimize overall cellular well-being, contributing to graceful aging and enhanced longevity.
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INGREDIENTS
Arginine Alpha-Ketoglutarate
Arginine Alpha-Ketoglutarate (AAKG) is a vital molecule in the tricarboxylic acid (TCA) cycle, a central pathway for energy production in cells, and is critical in cellular energy metabolism and functions such as DNA and protein synthesis. AAKG acts as a precursor to nitric oxide (NO), a signaling molecule involved in various cellular processes. By supporting nitric oxide production, AAKG promotes blood flow and oxygen delivery to tissues, optimizing mitochondrial function. Furthermore, AAKG exhibits potent antioxidant properties, reducing oxidative stress and preserving mitochondrial integrity. The combined effects of AAKG on nitric oxide production, blood flow, oxygen delivery, and antioxidation contribute to its ability to promote longevity.1,2
Trimethylglycine
Trimethylglycine (TMG), also known as betaine anhydrous, is a naturally occurring compound with diverse physiological functions. TMG acts as a methyl donor, supporting DNA and histone methylation, which play critical roles in gene expression regulation and maintaining cellular function. By modulating gene expression, TMG helps optimize cellular function and contributes to its longevity-promoting effects.3,4
Bergamote®
Natural polyphenols found in fruits, vegetables, and tea exhibit antioxidant activity, modulation of cell signaling pathways, DNA methylation, and apoptosis. Bergamote® (bergamot orange extract), rich in polyphenols such as flavonoids and citrus bergamia polyphenols (CBPs), offers multiple mechanisms of action that promote longevity. Its potent antioxidant properties neutralize reactive oxygen species (ROS). It has been shown to support cardiovascular health and support healthy cholesterol, blood sugar levels and weight management.5,6,7 Additionally, bergamot orange extract supports endothelial function, promoting blood flow and cardiovascular health.8,9
Epigallocatechin Gallate
Epigallocatechin gallate (EGCG), a polyphenol found in green tea, promotes longevity through various mechanisms. EGCG scavenges free radicals and protects cellular components as a potent antioxidant. Furthermore, EGCG supports autophagy, a cellular process that clears damaged proteins and organelles, promotes cellular function and support longevity.10,11
Taxifolin
Taxifolin, also known as dihydroquercetin, is a flavonoid found in various plant sources that exhibits diverse mechanisms of action contributing to its longevity-promoting effects. It acts as a potent antioxidant, effectively scavenging free radicals and limiting oxidative stress, which can lead to cellular damage and aging. Additionally, taxifolin supports mitochondrial biogenesis and promotes electron transport chain activity, resulting in energy production and cellular respiration.12,13
Spermidine
Spermidine is a polyamine naturally present in various foods and cells. It plays a crucial role in cellular processes such as autophagy and gene expression regulation. Spermidine promotes autophagy, which removes damaged cellular components and supports cellular rejuvenation. By supporting autophagy, spermidine helps maintain cellular health. It also exhibits antioxidant properties, protecting cells from oxidative damage. Furthermore, spermidine optimizes gene expression by interacting with chromatin and influencing histone modifications, contributing to cellular homeostasis and longevity.14,15 -
REFERENCES
1. Allerton TD, Proctor DN, Stephens JM, Dugas TR, Spielmann G, Irving BA. Nutrients. 2018 Jul 19;10(7):921. doi: 10.3390/nu10070921. PMID: 30029482; PMCID: PMC6073798. https://doi.org/10.3390/nu10070921
2. Boccardi V , Paolisso G, Mecocci P . Aging (Albany NY). 2016 Jan;8(1):12-5. doi: 10.18632/aging.100886. https://doi.org/10.18632/aging.100886
3. Shay J, Elbaz HA, Lee I, Zielske SP , Malek MH, Hüttemann M. Oxid Med Cell Longev. 2015;2015:181260. doi: 10.1155/2015/181260. https://doi.org/10.1155%2F2015%2F181260
4. Y ao HT, Li CC, Chang CH. E Nutrients. 2019 Aug 10;11(8):1862. doi: 10.3390/nu11081862. https://doi.org/10.3390/nu11081862
5. Ross Walker, Elzbieta Janda and Vincenzo Mollace. Cardiac Health and Polyphenols. Chp 84, Pg 1085-1103, 2014. http://dx.doi.org/10.1016/B978-0-12-398456-2.00084-0
6. Micaela Gliozzi, Ross Walker, Elzbjeta Janda, Vincenzo Mollace. International Journal of Cardiology Dec 2013, 170(2):140-5. https://doi.org/10.1016/j.ijcard.2013.08.125
7. Vincenzo Mollace, Iolanda Sacco, Elzbieta Janda, Claudio Malara, Domenica V entrice, Carmen Colica, V aleria Visalli, Saverio Muscoli. Fitoterapia 82 (2011) 309–316. https://doi.org/10.1016/j.fitote.2010.10.014
8. Liu P , Huang J, Mei W, Zeng X, Wang C, Wen C, Xu J. Bioengineered. 2021 Dec;12(2):9496-9506. doi: 10.1080/21655979.2021.1996018. https://doi.org/10.1080%2F21655979.2021.1996018
9. Saini RK, Ranjit A, Sharma K, Prasad P , Shang X, Gowda KGM, Keum YS. Antioxidants (Basel). 2022 Jan 26;11(2):239. doi: 10.3390/antiox11020239. https://doi.org/10.3390%2Fantiox11020239
10. Inoue, T., Saito, S., Tanaka, M., Y amakage, H., Kusakabe, T., Shimatsu, A., Ihara, M., & Satoh-Asahara, N. (2019). Proceedings of the National Academy of Sciences, 116(20), 10031–10038. https://doi.org/10.1073/pnas.1901659116
11. Chirumbolo S. Inflamm Allergy Drug Targets. 2010 Sep;9(4):263-85. https://doi.org/10.2174/187152810793358741
12. Emile Andriambeloson and others, The Journal of Nutrition, V olume 128, Issue 12, December 1998, Pages 2324–2333, https://doi.org/10.1093/jn/128.12.2324
13. Li J, Sun M, Cui X, Li C. Int J Mol Sci. 2022 Sep 2;23(17):10020. https://doi.org/10.3390%2Fijms231710020
14. Madeo F, Zimmermann A, Maiuri MC, Kroemer G. J Clin Invest. 2015 Jan;125(1):85-93. https://doi.org/10.1172%2FJCI73946
15. Eisenberg, T., Knauer, H., Schauer, A. et al. Nat Cell Biol 11, 1305–1314 (2009). https://doi.org/10.1038/ncb1975
| Ingredients | Amount Per Serving |
| Arginine Alpha-Ketoglutarate | 500 mg |
| Trimethylglycine (TMG) (as Betaine Anhydrous) | 500 mg |
| Bergamont Orange Extract (citrus bergamia) (Fruit) (Bergamonte®) (38% Bergamot Polyphenolic Fraction® comprised of Neohesperidin, Naringin, Neoeriocitrin, Brutierifin and Melitidin) | 250 mg |
| Epigallocatechin Gallate (EGCG) (from Green Tea 98% Extract) | 100 mg |
| Taxifolin (from Dihydroquercetin) | 10 mg |
| Spermidine | 10 mg |
Other Ingredients: Vegetable Capsule (Hypromellose, Titanium Dioxide)
Professional Information
People Requiring:
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Anti-Aging Protocols
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High Levels of Physical Activity
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Mitochondrial Support
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Cardiovascular Support
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OMICm Age & Pace of Aging Optimization*
FAQs
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What is InfiniWell Enhance?
Enhance by InfiniWell is part of the InfiniWell longevity supplements collection, created to support cellular function, immune system resilience, and other age-related changes.This anti-aging supplement combines well-researched compounds to promote mitochondrial function, detoxification pathways, and stamina—areas that often need extra support in older adults as dietary patterns change and metabolic activity slows. -
What are the benefits of Enhance?
Enhance is formulated to support the body’s natural cellular defense mechanisms while promoting vitality, energy, and stamina.Key benefits include:- Healthy aging support: A balanced combination of ingredients that promote normal cellular activity and assist with natural detox pathways, helping the body adapt to age-related changes.
- Mitochondrial health: Nutrients that help manage mitochondrial free radicals, which supports efficient cellular energy production and overall metabolic balance.
- Cardiovascular function: Compounds that help maintain healthy blood vessel function and lipid levels—essential for heart health as we age.
- Physical endurance and stamina: Nutritional support for sustained energy, muscle efficiency, and physical performance, especially helpful for active adults.
- Blood sugar and lipid metabolism: Ingredients that help maintain normal blood glucose and cholesterol levels, promoting steady energy and metabolic wellness.
- Muscle maintenance and protein synthesis: Support for preserving muscle mass and natural protein production, which become harder to maintain with age.
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What are the ingredients in Enhance?
Each three-capsule serving of Enhance contains a targeted blend of nutrients designed to support cellular health, metabolism, and longevity:- Arginine alpha-ketoglutarate: Supports nitric oxide production and protein metabolism, which may help promote circulation and support muscle integrity and cognitive function.
- Trimethylglycine (betaine): Supports methylation and homocysteine balance, helping manage metabolism and maintain cellular energy, especially in older adults.
- Bergamot orange extract (Bergamonte®): Supports healthy cholesterol and blood sugar metabolism, with additional benefits for heart and brain health.
- Epigallocatechin gallate (EGCG): A potent antioxidant found in green tea that helps neutralize free radicals and may support immune health, skin aging, and mental clarity.
- Taxifolin: A plant flavonoid that supports antioxidant defense, cognitive performance, and overall cellular health.
- Spermidine: A naturally occurring compound studied for its ability to support autophagy (the body's process of clearing out old or damaged cell components) and longevity, with potential benefits for brain function and protection against age-related cellular changes.
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What makes Enhance one of the best longevity supplements?
Unlike many dietary supplements, Enhance is formulated to support multiple systems affected by the aging process, not just one. It targets key cellular pathways that play a role in long-term health and performance, including:- Autophagy: Supports the body’s natural cellular recycling process, which helps clear out damaged components and maintain cellular function.
- Mitochondrial function: Helps support the body’s energy production at the cellular level, promoting vitality and stamina.
- Nrf2 pathway support: Assists the body's natural detox and antioxidant response, helping protect against everyday environmental stressors.
- Protein synthesis and energy metabolism: Supports the body’s ability to maintain muscle mass, manage blood sugar levels, and fuel physical activity.
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How does Enhance support stamina and endurance?
Enhance includes amino acid derivatives and polyphenols that support energy metabolism and mitochondrial function. This helps the body sustain physical activity and maintain performance levels, especially for individuals with active lifestyles.Ingredients like arginine alpha-ketoglutarate support nitric oxide pathways, while trimethylglycine supports energy balance and methylation—a process involved in gene expression, where cells use genetic instructions (DNA) to make proteins—and overall metabolic function. -
What is the best supplement for endurance and stamina?
Needs can vary, but supplements that support mitochondrial health, nitric oxide production, and energy metabolism are often a good fit. Enhance supports all three, making it a strong option for those who want to stay active and maintain performance with age. -
What is autophagy, and how does Enhance support it?
Autophagy is the body’s process of cleaning out damaged or aged cell components to make room for healthier ones. Enhance contains spermidine, a naturally occurring compound studied for its support of autophagy. This helps maintain normal cellular turnover, an important part of healthy aging. -
Can Enhance support blood sugar and lipid metabolism?
Yes. Enhance includes Bergamonte (a specific type of bergamot extract) and trimethylglycine, which support blood sugar balance and lipid metabolism. These ingredients contribute to normal metabolic function and cardiovascular wellness.If you’re looking for supplements for blood sugar support, Enhance offers ingredients that help maintain glucose and lipid homeostasis (the body’s ability to balance fats like cholesterol and triglycerides). -
Which ingredients in Enhance support antioxidant defenses?
Enhance includes several compounds known for their antioxidant properties:- Epigallocatechin gallate (EGCG): Found in green tea, EGCG supports cellular defense against oxidative stress.
- Taxifolin: A plant-derived flavonoid that supports antioxidant activity and cellular protection.
- Spermidine: Studied for its role in cellular maintenance and protection.
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What is mitochondrial function, and why does it matter?
Mitochondria are the energy-producing structures inside your cells. As we age, mitochondrial efficiency may decline. InfiniWell's Enhance includes ingredients that support mitochondrial health and antioxidant defenses, helping preserve the energy your cells need to function. -
What is the Nrf2 pathway, and how does Enhance support it?
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a cellular pathway involved in the body's antioxidant and detoxification processes. Enhance includes nutrients that support the natural activation of this pathway, helping the body respond to environmental stress and maintain overall resilience. -
How does Enhance support protein synthesis and muscle health?
Enhance contains arginine alpha-ketoglutarate, which supports nitric oxide production and amino acid metabolism—both important for protein synthesis and muscle mass maintenance. This makes it a relevant supplement for adults focused on staying active and maintaining muscle health as they age. -
How should I take InfiniWell Enhance?
The recommended serving is three capsules per day, taken with water. Enhance is intended for oral use and can be taken once daily as part of your regular supplement routine or as directed by your healthcare provider. -
Does Enhance contain any stimulants?
No. Enhance does not contain caffeine or other stimulant ingredients. It is a stimulant-free formula suitable for long-term use, whether taken during the day or in the evening. -
Who is Enhance for?
Enhance is for adults looking for:- Cellular renewal and detox support
- A non-stimulant formula to support daily energy
- Mitochondrial and cardiovascular health support
- Supplement-based support for endurance and stamina
- Supplements for healthy aging
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What makes InfiniWell longevity supplements different?
InfiniWell longevity supplements, including Enhance, are:- Thoughtfully formulated: Backed by current scientific research and human health studies
- Transparency-driven: Clearly labeled with no unnecessary additives
- Targeted: Designed to support distinct aspects of cellular aging and function
- GMP-compliant: Manufactured in facilities that follow Good Manufacturing Practices to ensure quality and consistency
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What other supplements can I take for healthy aging?
In addition to a longevity formula like Enhance, many adults turn to other nutrients and lifestyle approaches to support healthy aging. While results vary, some supplements, anti-aging vitamins, and lifestyle habits are commonly used to support cellular function, antioxidant activity, and long-term wellness:- Vitamin C: Known for its antioxidant properties; supports skin health, collagen formation, and the body’s natural defense against oxidative stress and skin damage.
- Vitamin E: Helps protect cell membranes from free radical damage and may support immune function and cognitive health as you age.
- Vitamin D: Essential for maintaining bone health, immune function, and mood. Low levels are especially common in older adults.
- Alpha lipoic acid: Supports energy metabolism and may also promote nerve health and antioxidant activity.
- Resveratrol supplements: Sourced from grapes and berries; studied for their potential to support cardiovascular health and mimic some effects of calorie restriction.
- Selenium: A trace mineral that supports thyroid function and helps the body neutralize oxidative stress; often included in vitamin blends for aging support.
- Curcumin supplementation: Derived from turmeric, which is known for its antioxidant properties, and explored for its potential to promote cellular resilience and joint health.
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Are there lifestyle habits that support healthy aging?
Yes. In addition to supplements, certain daily habits are often recommended to support healthy aging and overall wellness:- Using broad-spectrum sunscreen: Helps protect against sun-related skin damage and may prevent signs of premature skin aging.
- Including fatty fish in your diet: Provides omega-3s that support heart health, brain health, and a normal antioxidant response.
- Choosing whole grains: Adds fiber and nutrients that support digestion, metabolic health, and stable blood sugar levels.
- Following a Mediterranean diet: Rich in healthy fats, vegetables, lean proteins, and whole foods; supported by extensive medical research for promoting long-term health and aging well.
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Should you take longevity supplements?
Longevity supplements can be a valuable part of a wellness routine, especially for the aging population. While aging is an inevitable process, certain nutrients may offer beneficial effects that support the body as it changes over time.These supplements are often designed to support key functions tied to long-term health, including bone health, blood glucose balance, and mental health. Some also contain compounds that help protect cell membranes, promote skin hydration, and may even help improve skin texture—factors often impacted by age-related changes.
Although they aren’t meant to replace prescription medications or treatments, longevity formulas like Enhance can provide added support for cellular function, energy, and resilience as you age. -
Where to buy Enhance
You can purchase Enhance directly through the InfiniWell website or from authorized online retailers.When choosing the best longevity supplement, look for formulas that:
- Include science-backed ingredients
- Support multiple aging pathways
- Are manufactured to high-quality standards
- Use transparent labeling
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Glossary
Key terms to know:- Aging process: The gradual changes in cells and tissues over time, often associated with decreased energy, resilience, and metabolic function.
- Arginine alpha-ketoglutarate: A compound that supports nitric oxide production, circulation, and protein metabolism.
- Autophagy: A natural process in which the body recycles damaged cell parts to maintain cellular health.
- Bergamonte: A trademarked extract from bergamot oranges, studied for its cardiovascular and metabolic support properties.
- EGCG: A catechin found in green tea known for its antioxidant properties.
- Glucose homeostasis: The body’s ability to maintain stable blood sugar levels within a healthy range.
- Lipid metabolism: The breakdown and processing of fats such as cholesterol and triglycerides in the body.
- Methylation: A biochemical process that contributes to gene expression and metabolic balance.
- Mitochondrial function: The efficiency and health of mitochondria, which produce energy for cells.
- Nitric oxide (NO): A molecule produced from arginine that helps support blood vessel function and circulation.
- Nrf2 pathway: A cellular mechanism that regulates the body’s antioxidant and detoxification responses.
- Spermidine: A naturally occurring polyamine—a type of compound involved in cell growth and function—studied for its role in autophagy and cellular maintenance.
- Taxifolin: A flavonoid that supports antioxidant defenses and helps maintain overall cellular health.
- Trimethylglycine: Also known as betaine; supports methylation and metabolic processes.